Background :
@EN Transforming growth factor-(TGF-α) is a acidic, heat-stable, 50 amino acid polypeptide which is related to cellular proliferation, malignant transformation, and angiogenesis. There are many similarities, between keratoacanthoma(KA) and
squamous
cell carcinoma(SCC). So, it is often difficult to differentiate keratoacanthoma and squamous cell carcinoma, clinically and histologically.
@ES Objective :
@EN Our purpose was to examine the patterns of TGF-αexpression on KA and SCC using immunohistochemical staining and to evaluate the usefulness of the immunohistochemical staining with antihuman TGF-α andtibody on differentiation between KA and
SCC.
@ES Methods :
@EN Formalin-fixed, paraffin-embedded specimens that had confirmed to KA(n=12) or SCC(n=10) were performed by immunoperoxidase staining with monoclonal antihuman TGF-αantibody
@ES Results :
@EN All of KA demonstrated a diffuse pattern within tumor lobules, but, at the peripheral rim of cells, showed unstained pattern, In contrast to KA, 40% of the SCC had patchyinfiltration within tumor lobules, and 60% of the SCC had diffuse
pattern
which
was similar to the pattern found in KA. All of SCC showed well-defined staining at peripheral cells.
@ES Conclusion :
@EN Immunohistochemical staining with antihuman TGF-αantibody could be used on differentiation between KA and SCC. (Kor J Dermatol 1996;34(1) : 227~232)
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